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Receptor tyrosine kinases (RTKs) are cell-surface receptors that regulate cellular processes including cell cycle, survival, differentiation, and migration. Aberrant RTK signaling is often observed in cancer, and many cancer drugs targeting RTKs have already been introducedThis article was published on the web ahead of print in MBoC in Press (http://www .molbiolcell.org/cgi/doi/10.1091/mbc.E17-04-0261) on September 13, 2017. J.A.M.M., V.K.O., A.M.K., A.T.P., and K.E. designed the study; J.A.M.M., V.K.O., and also a.M.K. carried out experimentation; J.A.M.M., V.K.O., A.M.K., A.T.P., and K.E. analyzed the data; and J.A.M.M. and K.E. wrote the manuscript. The authors declare that they have no conflict of interests. *Address correspondence to: Klaus Elenius ([email protected]). Abbreviations made use of: ADAM, disintegrin and metalloprotease; CTF, carboxy-terminal fragment; DAPI, 4′,6-diamidino-2-phenylindole; EGFR, epidermal development factor receptor; FCS, fetal calf serum; FGFR4, fibroblast development factor rec.
